Research on efficient synthetic method of β- and δ-carbolines using a Copper catalyst
DOI:
https://doi.org/10.51316/jca.2022.069Keywords:
C-N coupling, Ulmann reaction, β-carboline, δ-carboline, copper catalysisAbstract
Methodology for synthesizing of β- and δ-carboline via two steps reaction from 2,3-dibromopyridine and 3,4-dibromopyridine. The intermediate was prepared from the substrate with o-bromophenylboronic acid via site-selective Suzuki-Myaura reaction, then, the final products were obtained by double C-N coupling via the Ulmann reaction of the intermediate with the corresponding amine with copper catalyst.
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