Development of bimetallic catalyst system (Pd and Cu) for the synthesis of 8-methyl-5-aryl-5H-pyrido[2',1':2,3]imidazo[4,5-b]indoles
Abstract
A highly efficient four-step procedure to prepare 8-methyl-5-aryl-5H-pyrido[2',1':2,3]imidazo[4,5-b]indoles was reported. The key step involves double C-N coupling reactions of 2-(2-bromophenyl)-3-iodo-6-methylimidazo[1,2-a]pyridine with amines catalyzed using the bimetallic catalyst (Pd-Cu).
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