Research on efficient synthetic method of   β- and δ-carbolines using a Copper catalyst

Ban Van Phuc; Nguyen Minh Quan; Nguyen Hien; Nguyen Quyet Tien; Truong Thi Thanh Nga; Nguyen Ngoc Tuan; Nguyen Quang An; Cu Hong Hanh; Dang Thanh Tuan; Tran Quang Hung

doi:10.51316/jca.2022.069

Authors

Ban Van Phuc Institute of Chemistry, Vietnam Academy of Science and Technology Author
Nguyen Minh Quan Graduate University of Sciences and Technology, Vietnam Academy of Science and Technology Author
Nguyen Hien Faculty of Chemistry, Hanoi National University of Education Author
Nguyen Quyet Tien Institute of Chemistry, Vietnam Academy of Science and Technology Author
Truong Thi Thanh Nga Institute of Chemistry, Vietnam Academy of Science and Technology Author
Nguyen Ngoc Tuan Institute of Chemistry, Vietnam Academy of Science and Technology Author
Nguyen Quang An Institute of Chemistry, Vietnam Academy of Science and Technology Author
Cu Hong Hanh Faculty of Chemistry, Hanoi National University of Education Author
Dang Thanh Tuan Faculty of Chemistry, University of Science, Vietnam National University, Hanoi, 19 Le Thanh Tong, Hoan Kiem, Hanoi, Vietnam Author
Tran Quang Hung Institute of Chemistry, Vietnam Academy of Science and Technology Author

DOI:

https://doi.org/10.51316/jca.2022.069

Keywords:

C-N coupling, Ulmann reaction, β-carboline, δ-carboline, copper catalysis

Abstract

Methodology for synthesizing of β- and δ-carboline via two steps reaction from 2,3-dibromopyridine and 3,4-dibromopyridine. The intermediate was prepared from the substrate with o-bromophenylboronic acid via site-selective Suzuki-Myaura reaction, then, the final products were obtained by double C-N coupling via the Ulmann reaction of the intermediate with the corresponding amine with copper catalyst.

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