Synthesis of Fe3O4/Au/Eu(TTA)3-folate nanomaterial for applications in biomedical

Hoang Thi Khuyen; Tran Thu Huong; Pham Thi Lien; Nguyen Vu

doi:10.51316/jca.2021.111

Authors

Hoang Thi Khuyen Institute of Materials Science, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam | Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam Author
Tran Thu Huong Institute of Materials Science, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam | Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam Author
Pham Thi Lien Institute of Materials Science, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi 10000, Viet Nam Author
Nguyen Vu Institute of Materials Science, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi 10000, Viet Nam Author

DOI:

https://doi.org/10.51316/jca.2021.111

Keywords:

Functionalization, folate, multifunctional, nanocomposite, Eu(TTA)3

Abstract

The Fe₃O₄/Au/Eu(TTA)₃ nanocomposite was functionalized with amino groups, which folic acid was attached to the amino groups to permit targeting of certain cancer cell lines that express high levels of folate receptor. In this paper, a Fe₃O₄/Au/Eu(TTA)₃-folate nanocomplex was successfully synthesized. The as-synthesized material has small size from 75 to 100 nm in diameter and good dispersity in solution. In addition, this nanocomplex exhibits strong emission at λmax = 614 nm, superparamagnetic properties and high biocompatibility.

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