Synthesis, structure and anticancer activities of Zn(II), Cd(II) complexes with 5,7-dichloro-8-hydroxyquinoline-2-carboxaldehyde-4-methyl-3-thiosemicarbazone

Ninh Thi Minh Giang; Nguyen Thi Bich Ngoc; Le Thi Hong Hai

doi:10.51316/jca.2021.107

Authors

Ninh Thi Minh Giang Tay Nguyen University Author
Nguyen Thi Bich Ngoc Hanoi National University of Education Author
Le Thi Hong Hai Hanoi National University of Education Author

DOI:

https://doi.org/10.51316/jca.2021.107

Keywords:

Structure, Zn(II), Cd(II) complexes, 5,7-dichloro-8-hydroxyquinoline-2-carboxaldehyde-4-methyl-3-thiosemicarbazone, anticancer

Abstract

Two new complexes [Zn(QMS)] and [Cd(QMS)] were synthesized by reaction between MCl₂(M = Zn, Cd) with 5,7-dichloro-8-hydroxyquinoline-2-carboxaldehyde-4-methyl-3-thiosemicarbazone (H₂QMS). Their structures were determined by ESI-MS, IR and ¹H NMR spectroscopies. The results showed that in these complexes the ratio of M(II) : H₂QMS ligand is 1 : 1, M(II) is bound to H₂QMS ligand through O, N_quinoline, N_{thiosemicarbazide} and S atoms. The complexes were tested for cell in vitro cytotoxicity on human cancer cells including KB, Hep-G2, LU and MCF-7. The results showed that ZnQMS complex exhibits high antitumor activities on KB, Hep-G2, Lu cancer cell lines with IC₅₀ values 9,41; 5,53 and 6,73 μM respectively. CdQMS complex gives a high activity against on LU cancer cell line with IC₅₀ value 4,54 μM.

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