Study on Preparation and Characterization of Chitosan-Fucoidan-Curcumin Nanoparticles System

Abstract

The chitosan-fucoidan-curcumin nanosystems was synthesized by a simple polyelectrolyte self-assembly method together with the inclusions of complex system. The process was carried out with ultrasonic assistant and heating stirring. This nanosystem was not degraded when passing through the stomach, it was effectively released in the intestine, increasing absorption and bioavailability. The parameters of chitosan, fucoindan, curcumin, cyclodextrin were investigated to achieve a concentration higher nano curcumin. The total amount of chitosan and fucoidan was 10%, 13%, 15%, 17%, and 20% of the total agents. The corresponding amounts of curcumin were such that chitosan, fucoindan, and curcumin remained constant at 30%. Cyclodextrin was added as 70%. The characteristics of the nanosystems have been determined by SEM, TEM, FTIR, and HPLC methods. As a result, the chitosan-fucoidan-curcumin nanosystems has been successfully synthesized, the nanoparticles have uniform sizes and are in the range of 30-100 nm. The maximum nano curcumin content is 15%. The suitable conditions of the reaction at 80^oC, the content of chitosan 7.5%, fucoidan 7.5%, curcumin 15%, and cyclodextrin 70%.