Development and Multi-Objective Optimization of Cosmetic Cream Formulations Using Artificial Neural Networks and Genetic Algorithms
DOI:
https://doi.org/10.62239/Keywords:
I(14)-HL(2)-O(4), genetic algorithm, simplex lattice mixture design, Advanced formulationAbstract
In recent years, demand for herbal cosmetics has grown due to their safety, efficacy, and eco-friendliness. Yet, herbal skincare formulations often lack standardization, leading to variable quality. This study focuses on developing and optimizing a herbal moisturizing cream using artificial intelligence (AI) in formulation design. Fourteen natural ingredients, including aloe vera, shea butter, almond oil, hyaluronic acid, and essential oils, were combined into 30 experimental formulations through a Simplex Lattice mixture design. Key properties—pH, viscosity, permeation, and moisturizing ability—were measured and modeled using a fuzzy logic neural network integrated with a genetic algorithm. The optimal formula was then evaluated for texture, absorption, spreadability, and stability. Integrating I(14)-HL(2)-O(4) with genetic algorithms highlights an effective approach for standardizing and optimizing herbal cosmetic formulations, offering a scientific basis for creating high-quality, consistent skincare products.
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References
D.C. Montgomery, Design and Analysis of Experiments, 9th ed., Wiley, Hoboken, NJ, USA, 2017.
L.A. Zadeh, Fuzzy logic = computing with words, IEEE Trans. Fuzzy Syst., 4(2) (1996) 103–111. https://doi.org/10.1109/91.493904
B. Singh, D.K. Sharma, Artificial neural networks in pharmaceutical product and process development, in Artificial Intelligence in Drug Delivery, Elsevier, 2021, 69–94.
J.H. Holland, Adaptation in Natural and Artificial Systems: An Introductory Analysis with Applications to Biology, Control, and Artificial Intelligence, MIT Press, Cambridge, MA, USA, 1992. DOI: https://doi.org/10.7551/mitpress/1090.001.0001.
Noorain, Srivastava V, Parveen B, Parveen R. Artificial Intelligence in Drug Formulation and Development: Applications and Future Prospects. Curr Drug Metab. 24(9), 2023,622-634. doi: 10.2174/0113892002265786230921062205.
T.F. Tadros, Formulations of Emulsions and Suspensions, Wiley-VCH, Weinheim, Germany, 2018.
S. Bolton, C. Bon, Pharmaceutical Statistics: Practical and Clinical Applications, Marcel Dekker, New York, NY, USA, 2004.
Ministry of Health, Vietnamese Pharmacopoeia V, Medical Publishing House, Hanoi, Vietnam, 2017.
R. Wulandini, F.S. Irwansyah, N. Windayani, Formulation of facial cleansing gels using aloe vera as natural surfactant, J. Phys.: Conf. Ser., 1402(5) (2019) 055069. https://doi.org/10.1088/1742-6596/1402/5/055069
R. Wulandini, F.S. Irwansyah, N. Windayani, Journal of Physics: Conference Series, 1402(5) (2019) 055069. https://doi.org/10.1088/1742-6596/1402/5/055069
O. Braun-Falco, H.J.D. Korting, V. Zeitschrift, Normal pH value of human skin, Dermatol. Verwandte Geb., 37(3) (1986) 126–129. https://doi.org/10.1111/j.1439-0507.1986.tb01852.x
M. Devi, A.B. Thalkari, V.M. Thorat, Research Journal of Topical and Cosmetic Sciences, 13(1) (2022) 27–34. https://doi.org/10.52711/2321-5844.2022.00005
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Copyright (c) 2025 Le Thi Thanh Thuy, Vu Le Ha, Nguyen Le Hoang Son, Nguyen Le Nhat Thuong, Pham Nguyen Truc Linh, Pham Van Tat
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