Synthesis and evaluation of adsorption ability of 5-FU anti-cancer drug onto a metal-organic framework (ZIF-4)

My Nguyen; An Thanh Phan Dang; Vu Tuyet Luu; Duong Hoang  Dang; Binh Thanh  Nguyen; Phu Quoc Truong; Thai Minh Nguyen; Binh Thuc  Nguyen; Nam Nhat  Phan; Hoang Van  Nguyen

doi:10.62239/jca.2026.041

Authors

My Van Nguyen Ho Chi Minh City University of Education
An Thanh Phan Dang Ho Chi Minh City University of Education
Vu Tuyet Luu Ho Chi Minh City University of Education
Duong Hoang Dang Ho Chi Minh City University of Education
Binh Thanh Nguyen Ho Chi Minh City University of Education
Phu Quoc Truong Ho Chi Minh City University of Education
Thai Minh Nguyen Ho Chi Minh City University of Education
Binh Thuc Nguyen Ho Chi Minh City University of Education
Nam Nhat Phan Ho Chi Minh City University of Education
Hoang Van Nguyen Ho Chi Minh City University of Science - VNUHCM

DOI:

https://doi.org/10.62239/jca.2026.041

Keywords:

Drug delivery, MOFs, Anti-cancer, Biomedicine

Abstract

In this contribution, the efficient adsorption of the anti-cancer drug 5-fluorouracil (5-FU) onto ZIF-4 synthesized via a solvothermal approach was reported. The synthesized material exhibited an exceptional 5-FU adsorption capacity of 314.4 mg g^-1. Full characterizations of ZIF-4 were conducted using modern analytical techniques, elucidating its high crystallinity, thermal stability, and porous structure. The N₂ adsorption-desorption isotherms at 77K revealed a specific surface area of 417.7 m² g^-1. Batch adsorption studies demonstrated that the process best fits the Langmuir and pseudo-second-order kinetic models, indicating a monolayer chemisorption mechanism. These findings highlight the potential of ZIF-4 as a highly promising carrier for high-capacity drug delivery applications to support the anti-cancer therapy.

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